16 July 2019 – Publication of Uppsala University

Xufeng Liu, Rui Miao, Pia Lindberg and Peter Lindblad published results on ‘Modular engineering for efficient photosynthetic biosynthesis of 1-butanol from CO2 in cyanobacteria‘ in Energy & Environmental Science. Highlight is the modular approach to boost butanol production to 4.8 g/L by introducing and re-casting the 1-butanol biosynthetic pathway at the gene and enzyme levels, optimizing the 5′-regions of expression units for tuning transcription and translation, rewiring the carbon flux and rewriting the photosynthetic central carbon metabolism to enhance the precursor supply, and performing process development.